Butternut Squash Mac and Cheese with Toasted Panko and Spiced Cheese Sauce Recipe
Introduction
This Butternut Mac and Cheese offers a cozy twist on a classic comfort dish. Roasted butternut squash adds a subtle sweetness and vibrant color, balanced by a blend of warm spices and creamy cheese sauce. It’s perfect for family meals or entertaining a crowd.

Ingredients
- 1 lb butternut squash, cubed
- 1 tablespoon cinnamon
- 1 1/4 tablespoons paprika
- 1 1/4 tablespoons cayenne pepper
- 1 garlic clove
- 2 lb cavatappi pasta
- 8 tablespoons butter
- 1 tablespoon olive oil
- 3/4 cup panko bread crumbs
- 1/3 cup flour
- 2 cups whole milk
- 1/2 teaspoon nutmeg
- 1.5 cups shredded gruyere cheese
- 2 cups shredded white cheddar cheese
- Salt and pepper, to taste
- 3 tablespoons chives, chopped
Instructions
- Step 1: Preheat your oven to 400°F (200°C). In a small bowl, mix 1 tablespoon cinnamon, 1 tablespoon paprika, and 1/2 tablespoon cayenne pepper. Toss the cubed butternut squash with the spice mixture, then spread it on a baking sheet. Roast for 25-30 minutes until the squash is tender and easily pierced with a fork.
- Step 2: Transfer the roasted squash to a food processor. Add 1 garlic clove and blend until the mixture is smooth and creamy, scraping down the sides as needed. Set aside.
- Step 3: Meanwhile, bring a large pot of water to a boil. Add 1 tablespoon salt and the cavatappi pasta. Cook until just al dente according to package instructions. Drain and set aside.
- Step 4: In a large non-stick skillet, heat 2 tablespoons butter and 1 tablespoon olive oil over medium heat. Add the panko breadcrumbs and stir to combine. Press the breadcrumbs into an even layer and let toast without stirring for 2-3 minutes, until golden brown. Remove from heat and transfer to a plate to cool.
- Step 5: Using the same skillet, melt the remaining 6 tablespoons butter over medium heat. Whisk in the flour and gradually add the milk, stirring constantly until the sauce begins to thicken.
- Step 6: Reduce heat to low and whisk in 1/4 teaspoon nutmeg, 1/4 teaspoon paprika, 1/8 teaspoon cayenne pepper, and salt and pepper to taste. Stir in the butternut squash puree until fully combined.
- Step 7: Gradually add the shredded gruyere and white cheddar cheeses, stirring continuously until the cheese is completely melted and the sauce is smooth.
- Step 8: Add the cooked pasta to the cheese sauce and stir gently to coat all the noodles. Mix in half of the toasted panko breadcrumbs.
- Step 9: Transfer the mac and cheese to a serving dish. Sprinkle the remaining panko breadcrumbs on top along with the chopped chives for a fresh finish. Serve warm.
Tips & Variations
- For extra creaminess, stir in a splash of heavy cream or cream cheese to the sauce.
- If you prefer less heat, reduce the cayenne pepper or omit it entirely.
- Try substituting smoked paprika for regular paprika to add a smoky flavor.
- Use gluten-free flour and pasta to make this recipe gluten-free.
- For a crunchy topping, bake the assembled mac and cheese under the broiler for 2-3 minutes after adding the breadcrumbs.
Storage
Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat gently in the microwave or on the stovetop with a splash of milk to restore creaminess. This dish is best enjoyed fresh but can also be frozen for up to 1 month; thaw overnight in the fridge before reheating.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I use a different type of squash?
Yes, butternut squash works best due to its sweetness and texture, but you can substitute with acorn or kabocha squash. Adjust roasting time as needed.
What pasta can I use if I don’t have cavatappi?
Other short pasta shapes like elbow macaroni, rotini, or penne work well in this recipe as they hold the cheese sauce nicely.
Print
Butternut Squash Mac and Cheese with Toasted Panko and Spiced Cheese Sauce Recipe
- Total Time: 50 minutes
- Yield: 12 servings 1x
Description
This Butternut Mac and Cheese combines creamy roasted butternut squash with a rich blend of Gruyere and white cheddar cheeses, topped with toasted panko for a delightful crunch. A comforting twist on classic mac and cheese, enhanced with warming spices like cinnamon, paprika, and cayenne pepper for a subtle kick.
Ingredients
Squash and Seasoning
- 1 lb butternut squash, cubed
- 1 tablespoon cinnamon
- 1 1/4 tablespoons paprika (divided)
- 1 1/4 tablespoons cayenne pepper (divided)
- 1 garlic clove
Pasta
- 2 lb cavatappi pasta
- 1 tablespoon salt (for pasta water)
Cheese Sauce and Topping
- 8 tablespoons butter (divided)
- 1 tablespoon olive oil
- 3/4 cup panko bread crumbs
- 1/3 cup flour
- 2 cups whole milk
- 1/2 teaspoon nutmeg (divided)
- 1.5 cups shredded Gruyere cheese
- 2 cups shredded white cheddar cheese
- Salt and pepper, to taste
- 3 tablespoons chives, chopped
Instructions
- Roast the butternut squash: Preheat the oven to 400°F. In a small bowl, mix 1 tablespoon cinnamon, 1 tablespoon paprika, and 1/2 tablespoon cayenne pepper. Toss the cubed butternut squash with the seasoning blend, then spread it out on a baking sheet. Roast for 25-30 minutes until the squash is tender and easily pierced with a fork. Transfer the roasted squash to a food processor along with 1 garlic clove and blend until smooth and creamy, scraping down the sides as needed.
- Cook the pasta: While the squash roasts, bring a large pot of salted water to a boil. Add the cavatappi pasta and cook until just al dente according to package directions. Drain and set aside.
- Toast the panko bread crumbs: In a large non-stick skillet, heat 2 tablespoons butter and 1 tablespoon olive oil over medium heat. Add the panko bread crumbs and stir to coat them evenly in the butter and oil. Spread the panko into an even layer and let toast without stirring for 2-3 minutes or until golden brown. Remove from the skillet and place in a bowl to cool.
- Make the cheese sauce: Using the same skillet, melt the remaining 6 tablespoons of butter over medium heat. Whisk in the flour and continue to whisk for about 1-2 minutes to form a roux. Gradually whisk in the whole milk and keep stirring until the mixture thickens. Reduce heat to low and add 1/4 teaspoon nutmeg, 1/4 teaspoon paprika, 1/8 teaspoon cayenne pepper, salt, and pepper to taste. Stir in the roasted butternut squash puree until fully incorporated. Slowly add the shredded Gruyere and white cheddar cheeses, stirring continuously until the cheese is completely melted and the sauce is smooth.
- Combine pasta and sauce: Add the cooked pasta to the cheese sauce and gently fold together until all the pasta is coated.
- Serve: Mix half of the toasted panko into the mac and cheese. Transfer to a serving dish, then sprinkle the remaining panko on top along with fresh chopped chives for garnish. Serve warm.
Notes
- Roasting the butternut squash enhances its natural sweetness and adds depth to the flavor of the sauce.
- Adjust the cayenne pepper amount to your preferred spice level; this recipe offers a subtle heat.
- Using a mix of Gruyere and white cheddar creates a creamy yet sharp cheese sauce.
- To save time, the squash can be roasted a day ahead and kept refrigerated.
- For a gluten-free option, substitute panko and flour with gluten-free alternatives.
- Prep Time: 10 minutes
- Cook Time: 40 minutes
- Category: Main Dish
- Method: Roasting and Stovetop
- Cuisine: American
Keywords: butternut squash mac and cheese, creamy mac and cheese, roasted squash pasta, autumn recipes, comfort food, cheesy pasta, cavatappi mac and cheese

